I think "centerlock" is nikyo...?
Sankyo is a vertical wrist twist (kote hineri).
As soon as you get the person on their toes try throwing either forward or backward using the direction that their body is going in response to the pain. (I don't usually put the pain on the lock, well, not unless they're resisting, but I focus more on taking the person's balance by locking the wrist, elbow, shoulder, center all at once).
Tai-otoshi (body drop) is a nice forward takedown....there are lots more
If a throw is not possible, or you need to control, you can always switch to a side wrist crush (nikyo) or gooseneck (gokyo), wrist pin (yonkyo), or arm entanglement.
Traditionally, the "form" has a controlled takedown (either from the front or rear, using the elbow as a fulcrum) followed by a shoulder pin - a variation of a rear arm entanglement. (Except it's done seated/kneeling rather than standing).
Most beginners will try to turn their back to you (sometimes followed by a back fist), in order to take the pressure off the wrist. [See what happens when you try to be gentle to teach someone how to apply a technique...]
The problem of course, is that you *have to* do something different. My favourite is the Vulcan neck "pinch" (carotid/brachial plexus), back of the knee takedown.
But, as always, it depends on *how* the other person is moving too.