[QUOTE]is pressure point/ nerve striking really practical???[/QUOTE]
It really depends on how realistically you train with them. If you are in a system the teaches pressure point KO's on a non-moving person and expect to be able to perform the same KO on some pissed off psyco your chances are slim. Pressure points should never be a foundation, just another component of your training. The more you know, whether it's body mechanics, pressure points, psychology or kensiology, the better your chances are of applying the techniques you know. Pressure points are part of the reason some techniques work. I don't know what your training back ground is but if you have ever had any formal MA training, other than kick boxing, you will go through a lot of basics. Some of the basics you learn don't have much meaning till later when you start digging deeper. This is part of the reason it's said you don't start really learning anything till AFTER you get your black belt. Up to that point most of what you were doing was conditioning the body and mind for more advanced training. Once you have learned the basics you can continue on to peeling away the layers and understand why you strike certain areas a certain way.
If you are going into a fight thinking you are going to try hitting X points you may have a problem. If you have trained properly though you will be able to recognize openings and be able to use some points for an advantage. Pressure points can work if you have a proper understand of them and no mystical expectations of their use. Their not the ultimate weapon, just another tool.
As for your friend taking several shots and never having this reaction. There are certain ways of activating different points. Some are push points, some are rub points and others are hit points. Even if it's a hit point there has to be the proper angle and direction for activation. It could have been a lucky shot.